The theoretical basis of this paper is the PRED interaction in regional or inter regional time space scales. The factors that restrict regional social and economic development are very different in different regions because the PRED relationships have their own natures in the social and economic activities of various regions. The nature of regional sustainable development lies in the way to harmonize their internal relations and to approach the goal of rational allocation among population, material, energy and information flow in PRED process. This is the essential to Human Nature relationship. This paper take the Human Nature system as the theoretical basis. At first, the author studies the work beginning with the perception process, structure, function, dynamic evolution of Human Nature relationships. Secondly, the mechanism of regional PRED coordination and theoretical models and methods of regional sustainable development are discussed. Thirdly, the author inquire into the theoretical study of system regulation.