The regional sustainable development decision making supporting system (RSD DSS) is a computer based technology supporting environment for the group of decision makers to resolve regional sustainable development problems. The main trend of the RSD DSS is to emphasize on the combination of new computer technologies. This paper analyzes the following key technologies applied in RSD DSS: distributed network technology, management technology for qualitative model base and quantitative model base, information interinfiltrate technology, metasynthetic engineering technology, qualitative reasoning technology and fuzzy decision making technology. The pattern of RSD DSS based on the distributed network is different from that based on single computer. The author puts forward a new kind of RSD DSS, the Virtual DSS (V DSS). It is a logical network built on the physical network. Due to the virtual feature, the establishment of the V DSS will cost less investment than that of the physical network. The V DSS can be constructed as an open system according to the standards of Internet, a typical open system. The V DSS can keep high flexibility: the participant of V DSS can be changeable according to the problems of the regional sustainable development decision making. It is very urgent to set up the DSS of regional sustainable development in China’s coastal areas. Since the economy reform in 1978, great progresses of economy and society development have been made in those areas. However, there are also many problems that reduce the capacity of regional sustainable development of them, such as population problem, resource problem, environment problem and development problem. In order to resolve such multi regional problems, the author suggests that the V DSS be put into use in the regions.