The Planning of regional development is the substantial action of the regional sustainable development, and is an important means of brining about the regional sustainable development. These two bear an obvious relationship of means and goal. This paper discusses the related effect, dynamic mechanism and cooperation mechanism of their interaction. With these discussion, this paper puts forward that a turn from sole goal to multi goal as well as the main goal assured and the consideration taken into the social and ecological as well as economic factors are the main approaches to make the regional sustainable development realized.