This paper expounded the author’s research on the index system and knowledge rules for Geographic - Feature - Oriented Generalization, and an example of its application. The research approach is the integration of geo-science analysis & conclusion, map analysis, expert consulting, as well as GIS &. RS spatial analysis method, to extract, conclude and build them. The index system include three types as data, literal and graphic index , and on the other hand grouped by database generalization index and map visualization index. The knowledge rules include, in crosswise, geometric, structure and procedure knowledge, and in lengthways, the knowledge of geographic feature description, operator selection, algorithm selection, as well as specific geo-object oriented and specific region oriented knowledge. In the knowledge base, these knowledge rules are organized by three dimension of variables as generalization condition, generalization scope/level, and generalization actions. The example is the generalization of The Map of Transportation Network in Zhujiang Delta Economic Zone.