With regional integration continuously developing, it has become essential to establish good governance mechanism in regional development. Due to the strategic status of the Beijing-Tianjin-Hebei region, its collaborative governance has been even more important, but the region is also facing a number of challenges. In order to understand better the characteristics of regional governance in the Beijing-Tianjin-Hebei region and to propose some optimization approaches that can support the implement of regional planning, this study conducted a comparative analysis and built a three-dimensional research framework including participants, means of governance, and cooperation mechanisms. On the basis of this, we summed up the characteristics and pattern of change of regional governance in the Beijing-Tianjin-Hebei region, the Berlin-Brandenburg region, the Tokyo metropolitan area, and the Paris metropolitan area, especially with regard to their differences. The three conclusions are as follows: 1) Multi-subjects participation has been the essential characteristics of regional governance, whose authority-responsibility relationships must be unambiguous. In practice, multiple players have participated in the regional governance in the Beijing-Tianjin-Hebei region, but the relationships among them need to be clarified. Founding a regional institution would be a good chance to straighten these relationships. 2) Only when the administrative means, market mechanisms, and legislation are interrelated and interact positively, can regional governance be effective. However, the governance structure of the Beijing-Tianjin-Hebei region, which consists of good administrative means, limited market mechanisms, and inadequate legislation, shows some limitations. To fix the problems, enhancing legislation system shall be the priority and this in turn can promote the interaction between the government and the market. 3) An efficient multilateral consultation mechanism is indispensable, which could support decision making and dispute arbitration. In this respect, the Beijing-Tianjin-Hebei region has already had a good decision-making mechanism, but there are some inadequacies in dispute arbitration and supervision. It is necessary to speed up and improve the overall coordination mechanism, which can be applied to all aspects of the governance practice.