Using ArcGIS software as a basic platform, taking Du’an County as a case, and by the aid of spatial superimposing analysis and geographical statistical analysis methods among them, Regional Karst Rocky Desertification Information System, or RKRDIS, a specialty GIS based on Arc Objects, is designed out. In this system, specialty analytic model of Karst rocky desertification is taken as the nucleus, with spatial data as information materials, with the computer network as transport vehicle, in order to realize abstracting “information”from“data”. The information processing technology supports data analysis, query, display and management for Karst Rocky Desertification research, and provides spatial data analysis of Karst rocky desertification for dynamic monitoring, driving diagnosis, early- warming analysis, calamity assessment, and policy making. Development of this system involves a variety of knowledge and professional skills like GIS, software engineering, natural geography, remote sensing, database design, computer technology and, etc., and is indeed a comprehensive integration of multidisciplinary knowledge. In particular, space analysis on Karst desertification disaster data, such as temporal - spatial monitoring, drive diagnosis, etc., is a full incarnation of features unique to GIS technology, since assembly system development method and method of management of space data by using relationship database, system structure based on C/S model, customized user interface and complete user functions, can better satisfy the requirements for application by users. So this is definitely a beneficial attempt that GIS technological application has ever been made in Karst desertification disaster field. The system can provide new study methods and means for integrated assessment and analysis of Karst desertification by using geographical information system in combination with mathematical models, and for prevention and treatment of disasters in Karst desertification areas. Moreover, it is of particular importance for providing guidance to the scientific treatment and construction in Karst desertification areas.